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S2Spire 2 Guide
S2Spire 2 Guide

A patch-aware Slay the Spire 2 guide database for returning players who want tier lists, cards, relics, bosses, and build notes without forum digging.

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Source footage

Slay the Spire 2 video source library

A public editorial queue for gameplay videos, guide videos, still frames, transcript review, and page updates. Videos are research material; final articles are rewritten into original guide structure.

246Sources
66Pages
246Stills
77Players
239 sources already have editorial usage notes and are ready for transcript, screenshot selection, or on-page playback when rights and source URLs are clear.
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Sources

14 of 246
Boss tier listScreened

How to Beat Every Boss

How to Beat EVERY Boss in Slay the Spire 2 (Full Guide).mp4

Credit: Nerdy Hickey on YouTube

  • Turn boss fights into comparison criteria for the boss tier list.
  • Capture boss-phase screenshots for matchup severity notes.
  • Pull examples of greedy rewards that fail boss checks.
Watch videoOpen target page
Beat the Final Boss Then Got Erased gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Beat the Final Boss Then Got Erased

Beat the Final Boss in Slay the Spire 2... Then Got Erased.mp4

  • Extract late-game backup-plan and disruption notes.
  • Compare final-boss pressure against ordinary boss tiers.
  • Capture final boss screenshots for spoiler-aware sections.
Open target page
Burying Act 3 Bosses With Necrobinder gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Burying Act 3 Bosses With Necrobinder

Burying Act 3 Bosses (Final Bosses only) Slay the Spire 2 Necrobinder Ascension Level 10.mp4

  • Collect late-game Necrobinder boss-fight examples for tier notes.
  • Separate final-boss matchup notes from ordinary Act 3 hallway advice.
  • Capture replay and Soul sequencing moments that show how the kill is set up.
Open target page
Insatiable Hive Boss Theme gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listQueued

Insatiable Hive Boss Theme

Insatiable Hive Boss Theme Slay The Spire 2 OST.mp4

  • Use boss-theme footage for boss identity and source-library organization.
  • Avoid treating OST footage as matchup proof without combat turns.
  • Queue a follow-up need for readable boss combat screenshots and danger-window evidence.
Open target page
264 Card Final Boss Kill gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

264 Card Final Boss Kill

264 CARD DECK! Turn 1 Final Boss Kill (Ascension 10) – Broken Silent Build Slay the Spire 2.mp4

  • Use extreme final-boss footage to separate highlight scaling from repeatable prep.
  • Capture relic density, draw smoothing, and fallback defense before the kill turn.
  • Add warnings where a boss tier claim depends on unusual deck size or rare support.
Open target page
New Act 3 Boss Is Insane gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

New Act 3 Boss Is Insane

NEW Act 3 Boss Is Insane Now In SLAY THE SPIRE 2.mp4

  • Capture late-boss pressure windows for Act 3 tier notes.
  • Compare boss disruption against character-specific survival tools.
  • Turn high-pressure combat turns into tier evidence instead of spoilers.
Open target page
The New Act 3 Boss gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

The New Act 3 Boss

The NEW Act 3 Boss In SLAY THE SPIRE 2.mp4

  • Use Act 3 boss footage to validate late-game damage and block checks.
  • Capture boss-specific danger turns for spoiler-light matchup warnings.
  • Route boss pressure examples into boss tier-list confidence notes.
Open target page
Knowledge Demon Boss Fight gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Knowledge Demon Boss Fight

Slay the Spire 2 - Knowledge Demon Boss Fight (Act 2).mp4

  • Add Act 2 boss pressure windows to the boss tier list.
  • Capture mid-run damage, block, and draw-smoothing requirements.
  • Compare Knowledge Demon examples against broader mid-run boss preparation.
Open target page
Defect Last Boss Ascension 3 gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Defect Last Boss Ascension 3

Slay the Spire 2 ~ Defect is kinda broken (Last boss Ascension 3).mp4

  • Turn final-boss potion decisions into preparation checks.
  • Capture Defect boss windows where weak, block, and orb scaling interact.
  • Separate highlight scaling from the emergency tools that kept the run alive.
Open target page
Bosses Revealed First Look gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Bosses Revealed First Look

Slay the Spire 2 Bosses Revealed NOW! (FIRST LOOK).mp4

  • Convert first-look boss footage into matchup danger windows.
  • Create provisional boss tier language before full database pages exist.
  • Identify which decks need damage, block, scaling, or debuff answers.
Open target page
Defect Act 3 Last Boss Invincibility Build gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Defect Act 3 Last Boss Invincibility Build

Slay the Spire 2 How to beat ACT 3 Last Boss with The Defect (Invincibility Build).mp4

  • Explain setup thresholds before calling a boss plan invincible.
  • Capture Defect orb-state and defensive-lock examples for final-boss tier notes.
  • Route Defect-specific boss lessons back into character and build pages.
Open target page
Ascension Final Boss Feels Like a Regular Encounter gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Ascension Final Boss Feels Like a Regular Encounter

When Ascension Final Boss in Slay the Spire 2 Feels Like a Regular Encounter.mp4

  • Define the thresholds that make a final boss feel stable.
  • Separate enough block, damage, draw, and relic support from easy-fight claims.
  • Use stabilized final-boss footage to improve boss tier-list confidence labels.
Open target page
Doormaker Boss Fight gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

Doormaker Boss Fight

Slay the Spire 2 - Doormaker Boss Fight (Act 3).mp4

  • Capture Doormaker turn windows and disruption moments.
  • Convert boss footage into tier-list matchup warnings.
Open target page
How to Beat Every Elite gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Boss tier listScreened

How to Beat Every Elite

How to Beat EVERY Elite in Slay the Spire 2 (Full Guide).mp4

  • Turn elite-specific mechanics into comparison checks.
  • Capture Act 1 Overgrowth examples for damage and slow-effect warnings.
  • Use elite pressure as a baseline when ranking boss danger windows.
Open target page