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S2Spire 2 Guide
S2Spire 2 Guide

A patch-aware Slay the Spire 2 guide database for returning players who want tier lists, cards, relics, bosses, and build notes without forum digging.

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Source footage

Slay the Spire 2 video source library

A public editorial queue for gameplay videos, guide videos, still frames, transcript review, and page updates. Videos are research material; final articles are rewritten into original guide structure.

246Sources
66Pages
246Stills
77Players
239 sources already have editorial usage notes and are ready for transcript, screenshot selection, or on-page playback when rights and source URLs are clear.
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Sources

5 of 246
Stop Wasting Potions gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Potion tier listScreened

Stop Wasting Potions

Stop Wasting Potions (When to Use Them) Slay the Spire 2 Guide.mp4

  • Turn hold-versus-use timing into potion tier criteria.
  • Capture examples where immediate use beats saving a potion for later.
  • Separate emergency potions from route-shaping and boss-prep potions.
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Beginners Guide to Potions gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Potion tier listScreened

Beginners Guide to Potions

Beginners Guide To Potions How To Play Slay The Spire 2 (Early Access Gameplay).mp4

  • Show fight windows where a potion changes HP, upgrade, or route outcomes.
  • Explain potion value through HP preservation and next-fight flexibility.
  • Route boss-specific potion examples into potion tier notes.
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Only Starter Deck Challenge gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Potion tier listScreened

Only Starter Deck Challenge

Can YOU beat Slay the Spire 2 with ONLY the Starter Deck.mp4

  • Use route-discipline footage to judge when potions cover weak deck states.
  • Capture potion timing and reward-skip moments for tier caveats.
  • Keep challenge-run evidence caveated before it affects normal-run rankings.
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Defect Last Boss Ascension 3 gameplay source still
Playback pending: add a YouTube embed or owned/licensed video URL.
Potion tier listScreened

Defect Last Boss Ascension 3

Slay the Spire 2 ~ Defect is kinda broken (Last boss Ascension 3).mp4

  • Turn final-boss potion decisions into tier-list caveats.
  • Capture boss windows where weak, block, orb scaling, and emergency tools interact.
  • Separate highlight scaling from the potion support that kept the run alive.
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Potion tier listScreened

How to Beat Every Boss

How to Beat EVERY Boss in Slay the Spire 2 (Full Guide).mp4

Credit: Nerdy Hickey on YouTube

  • Compare potion value against boss-prep reward decisions.
  • Capture boss-phase screenshots where potion effects change matchup risk.
  • Pull examples of greedy routes that need potion backup before the boss.
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